Granulin anticorps (Internal Region)

N° du produit ABIN375134

L’anticorps Chèvre Polyclonal anti-Granulin a été validé pour WB. Il convient pour détecter Granulin dans des échantillons de Humain.

Aperçu rapide pour Granulin anticorps (Internal Region) (ABIN375134)

Antigène: Granulin (GRN)

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp Granulin est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Granulin anticorps

Épitope: Internal Region

Specificité: This antibody recognizes Granulin / GRN.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity Chromatography

Immunogène: Peptide with sequence QSKCLSKENATTD, from the internal region of the protein sequence according to NP_002078.1.

Information d'application

Indications d'application: Peptide ELISA: 1/8000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Granulin

Antigène: Granulin (GRN)

Autre désignation: Granulins (GRN)

Sujet: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Tissue specificity: In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney. Involvement in disease: Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD) [MIM:607485], also known as tau-negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.Synonyms: GRN, Granulins, PEPI, Proepithelin

Poids moléculaire: 63.5 kDa (NP_002078.1)

ID gène: 2896, 9606

UniProt: P28799